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HAT specificity and factor specificity of enzyme inhibitory actions. (A) Effects of E1A on p/CAF-dependent acetylation of histone H3. (B) Effect of CREB or CREB/E1A fusion protein or HAT activity of CBP on histone H3/H4. Neither CREB nor the CREB fusion protein inhibited CBP-dependent acetylation. Similar results were obtained with CBP/H3N E1A(1–242) fusion protein.
