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The conserved solvent-accessible residues on the surface of the FGF-2 structure. These residues form a van der Waals surface patch. A Connolly surface rendering of the FGF-2 generated by using Insight II with the solvent-accessible conserved amino acid residues colored in purple is shown. This site coincides with the primary receptor binding site identified on the basis of site-directed mutagenesis studies (33).
