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(a) Schematic representation of the receptor clustering and oligomerization resulting from a side-by-side oligomerization of FGF as in a “beads-on-a-string” model. (b) Schematic representation of the receptor dimerization induced by a FGF-1–HLGAG dimer as observed in the cocrystal structure of FGF-1–decasaccharide (41). This model is schematically similar to the model suggested by DiGabrielle et al. (41).
