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The SP release induced by itself from cultured adult rat DRG neurons. Time-dependent (A) and dose-dependent (B) effects of SP on its own release from cultured DRG neurons. (C) Effects of neurokinin receptor antagonists (1 μM CP-96,345, 1 μM SB222200 and 100 nM GR94800) on the SP release from cultured DRG neurons exposed to SP. The data are expressed as means ± S.E.M. (bars) from 3–5 (A), 4 (B) or 3 (C) separate experiments. *, ** and *** denote p < 0.05, 0.01 and 0.001, respectively.
