Table 1.
Human Gene Families used in Analysis
| Gene family | Members | Chr Location | Human Protein Accession No | Molecular Function |
| Fbrillar collagen family | ||||
| COL2A1 | 12q13.11-q13.2 | P02458 | Extracellular matrix structural constituent, Structural constituent of bone, Phosphate transport, Cell adhesion, Skeletal development, Perception of sound. | |
| COL3A1 | 2q31 | P02461 | ||
| COL5A2 | 2q14-q32 | Q7KZ55 | ||
| COL1A2 | 7q22.1 | P08123 | ||
| COL1A1 | 17q21.33 | P02452 | ||
| ERBB receptor protein-tyrosine kinase | ||||
| ERBB2 | 17q21.1 | Q96RT1 | Epidermal growth factor receptor activity, Protein serine/threonine kinase activity, Electron transporter activity, Cell proliferation, ATP binding. | |
| EGFR | 7p12 | P00533 | ||
| ERBB4 | 2q33.3-q34 | Q15303 | ||
| ERBB3 | 12q13 | P21860 | ||
| Insulin-like growth factor-binding protein | ||||
| IGFBP4 | 17q12-q21.1 | P22692 | Regulation of cell growth, Signal transduction, Skeletal development Cell proliferation. | |
| IGFBP1 | 7p13-p12 | P08833 | ||
| IGFBP2 | 2q33-q34 | P18065 | ||
| IGFBP6 | 12q13 | P24592 | ||
| IGFBP3 | 7p13-p12 | P17936 | ||
| IGFBP5 | 2q33-q36 | P24593 | ||
| Integrin beta chain family | ||||
| ITGB3 | 17q21.32 | P05106 | Receptor activity, Cell-matrix adhesion, Integrin-mediated signaling pathway. | |
| ITGB5 | 3q21.2 | P18084 | ||
| ITGB6 | 2q24.2 | P18564 | ||
| ITGB7 | 12q13.13 | P26010 | ||
| ITGB4 | 17q25 | P16144 | ||
| ITGB8 | 7p15.3 | P26012 | ||
| Myosin light chain | ||||
| MYL4 | 17q21-qter | P12829 | Phosphoprotein phosphatase activity, Structural constituent of muscle, Muscle development, Microfilament motor activity. | |
| MYL6 | 12q13.2 | P60660 | ||
| MYL1 | 2q33-q34 | P06741 | ||
| MYL7 | 7p21-p11.2 | Q01449 | ||
| MYL2 | 12q23-q24.3 | P10916 | ||
| Sp1 c2h2-type zinc-finger protein family | ||||
| SP1 | 12q13.1 | P08047 | RNA polymerase II transcription factor activity. | |
| SP2 | 17q21.32 | Q02086 | ||
| SP3 | 2q31 | Q02447 | ||
| SP4 | 7p15 | Q02446 | ||
| SP8 | 7p21.2 | Q8IXZ3 | ||
| Zinc finger protein, subfamily 1A | ||||
| ZNFN1A1 | 7p13-p11.1 | Q13422 | DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. | |
| ZNFN1A2 | 2qter | Q9UKS7 | ||
| ZNFN1A3 | 17q21 | Q9UKT9 | ||
| ZNFN1A4 | 12q13 | Q96JP3 | ||
| Anion exchanger family SLC4A (AE) | ||||
| SLC4A1 | 17q21-q22 | P02730 | Inorganic anion exchanger activity, Bicarbonate transport, Chloride transport. | |
| SLC4A2 | 7q35-q36 | P04920 | ||
| SLC4A3 | 2q36 | P48751 | ||
| SLC4A5 | 2p13 | Q14203 | ||
| SLC4A8 | 12q13 | O95233 | ||
| SLC4A10 | 2q23-q24 | Q9HCQ6 | ||
| GLI zinc-finger protein family | ||||
| GLI1 | 12q13.2-q13.3 | P08151 | Regulation of transcription from RNA polymerase II promoter, Morphogenesis of limb and brain. | |
| GLI2 | 2q14 | P10070 | ||
| GLI3 | 7p13 | P10071 | ||
| Hedgehog family | ||||
| SHH | 7q36 | Q15465 | Mesodermal cell fate determination, Proteolysis and peptidolysis, Cell-cell signaling, Intein-mediated protein splicing. | |
| DHH | 12q12-q13.1 | O43323 | ||
| IHH | 2q33-q35 | Q14623 | ||
| Inhibin | ||||
| INHBA | 7p15-p13 | P08476 | Cytokine activity, Growth factor activity, Induction of apoptosis, Mesoderm development, Defense response. | |
| INHBB | 2cen-q13 | P09529 | ||
| INHBC | 12q13.1 | P55103 | ||
| INHBE | 12q13.3 | P58166 |