Figure 1.

Promoter element sequence alignment of chicken, bovine and human 7SK promoters. The enhancer (DSE) of the chicken 7SK promoter contains OCT-1 and SPH motifs but no CACCC box. The basal promoter region features a PSE and TATA box with homology to consensus. Matches to the defined consensus sequences indicated at the top of the OCT-1 [21], SPH [12], PSE [20] and TATA sequences are shown in upper case. Nucleotides conserved between chicken and either bovine or human 7SK promoter elements are underlined. Nucleotide positions indicate the location (5' → 3') of each element in the promoter relative to the transcription start site (+1). Each dash mark between the OCT-1 and CACCC box and PSE and TATA box represents one nucleotide. Nucleotide abbreviations in consensus sequences are according to the International Union of Biochemistry convention for GENBANK.