Table 5.
IFNγ/IL-5 Ratios a
| Controls |
MS Patients |
|||||
|---|---|---|---|---|---|---|
| Stimulus |
C M |
C F |
P-value |
MS M |
MS F |
P-valueb |
| Candida | 5.8 | 3.0 | NS | 1.1 | 14.4 | <.0001c |
| Diphtheria | 6.3 | 4.7 | NS | 1.2 | 6.0 | NS |
| Streptokinase | 8.5 | 5.4 | NS | 2.3 | 6.7 | <.0001 |
| Tetanus tox. | 1.2 | 1.5 | NS | 2.8 | 2.4 | NS |
| TT 830−844 | 0.9 | 5.0 | <.0001 | 2.5 | 10.3 | <.0001 |
| TT 947−967 | 2.5 | 2.7 | NS | 1.5 | 9.9 | <.0001 |
| anti-CD3 | 7.2 | 6.6 | NS | 5.2 | 7.1 | <.0001 |
| PHA | 7.3 | 6.1 | NS | 5.4 | 8.9 | <.0001 |
| MBP | 13.3 | 8.7 | NS | 12.0 | 13.9 | NS |
| MBP 87−106 | 1.2 | 0.6 | NS | 0.5 | 1.3 | NS |
| MOG 1−22 | 2.5 | 4.8 | NS | 0.7 | 1.5 | NS |
| MOG 34−56 | 9.4 | 2.2 | NS | 1.5 | 6.5 | 0.0148 |
| MOG 64−96 | 8.1 | 3.0 | NS | 1.2 | 8.3 | <.0001 |
| PLP-10 | 0.1 | 1.8 | NS | 9.9 | 0.8 | NS |
| PLP-50 | 0.9 | 3.2 | NS | 1.2 | 0.5 | NS |
| PLP 40−60 | 0.8 | 2.2 | NS | 0.5 | 27.8 | <.0001 |
| PLP 89−106 | 8.8 | 0.9 | NS | 1.7 | 2.1 | NS |
| PLP 103−120 | 0.6 | 6.8 | 0.0010 | 6.2 | 10.2 | NS |
| PLP 139−158 | 0.5 | 2.3 | NS | 2.6 | 2.8 | NS |
| PLP 172−191 | 0.5 | 2.4 | NS | 2.5 | 5.5 | 0.0100 |
| PLP 195−206 | 0.5 | 7.1 | 0.0005 | 1.4 | 21.8 | <.0001 |
a
Ratios are the mean IFNγ response divided by the mean IL-5 response for all subjects in that group.
b
P values were calculated using a bootstrap analysis.
c
P values in bold represent IFNγ/IL-5 ratios where the female ratio is significantly increased compared to the male ratio (P ≤ .01) by a one-way students' T test. NS = not significant.