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Dendritic nucleation hypothesis. The association of Arp2/3 complex with Scar and the side of an actin filament activates nucleation of a new actin filament, which is capped at its pointed end by the Arp2/3 complex and which grows in the barbed direction as a branch of the older filament. The exact order of events is not yet known. Scar could bind to Arp2/3 complex before their association with the side of an actin filament.
