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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Neuropharmacology. 2007 Jun 22;54(1):95–107. doi: 10.1016/j.neuropharm.2007.05.028

Fig. 7.

Fig. 7

CB1 cannabinoid receptors are located presynaptically on GABAergic axon terminals in the ventral tegmental area. A–B) Immunoperoxidase (DAB) staining for CB1 shows that CB1 is also present on axon terminals (bCB1) forming symmetric synapses (double arrows) on immunonegative thick proximal dendrites (d) – corresponding probably to the large-sized granules observed in the light microscopic image in Fig. 5. C1–2) Two consecutive sections demonstrate that CB1 receptors labeled with immunogold particles (arrows) are present presynaptically on putative intrinsic GABAergic axon terminals (bCB1) giving rise to symmetric synapses (double arrows). D shows another CB1-positive bouton (bCB1) giving rise to GABAergic, symmetric synaptic contact onto an unlabeled dendrite (d). However this axon terminal differs from the one depicted in panel C1–C2, because it contains a large dense core vesicle (open arrow) and it is densely packed with small, often flattened synaptic vesicles. Scale bars: A–D, 0.2μm.