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Quantification of preimmunization, antipneumococcal polysaccharide serum IgG (a), IgA (b), and IgM (c) antibody levels in adults (n = 20; triangles) and 12-month-old toddlers (n = 23; circles). Antibody levels against pneumococcal serotypes 4, 14, and 23F were quantified by ELISA. The data are plotted as the log of the individual antibody concentrations (in μg/ml), and the bars represent the GMCs.
