TABLE 1.
Quantification of antipneumococcal polysaccharide serum antibody (IgG, IgA, and IgM) from 12-month-old toddlers prior to and following each of two doses of Pnc7 vaccine
| Serotype | Ig | GMC (μg/ml) of anti-pneumococcal polysaccharide serum antibody from 12-mo-old toddlers at the indicated times aftera:
|
|||
|---|---|---|---|---|---|
| First Pnc7 dose
|
Second Pnc7 dose
|
||||
| Day 0 | Day 6 or 7b | Day 56b | Day 62 or 63b | ||
| 4 | IgG | 0.02 (0.01-0.04) | 0.77 (0.52-1.16) | 2.16 (1.65-2.83) | 6.23 (4.42-8.78) |
| IgA | 0.02 (0.01-0.02) | 0.49 (0.34-0.71) | 0.20 (0.14-0.71) | 0.70 (0.51-0.97) | |
| IgM | 0.14 (0.11-0.17) | 1.12 (0.85-1.47) | 0.54 (0.42-0.68) | 0.98 (0.75-1.29) | |
| 14 | IgG | 0.05 (0.02-0.10) | 0.66 (0.38-1.14) | 2.78 (1.72-4.50) | 12.11 (9.44-15.55) |
| IgA | 0.02 (0.01-0.03) | 0.28 (0.20-0.40) | 0.15 (0.11-0.21) | 0.81 (0.62-1.07) | |
| IgM | 1.22 (0.98-1.52) | 5.90 (4.65-7.50) | 4.10 (3.22-5.21) | 8.34 (6.57-10.60) | |
| 23F | IgG | 0.02 (0.02-0.04) | 0.19 (0.10-0.36) | 0.33 (0.19-0.55) | 2.26 (1.35-3.78) |
| IgA | 0.01 (0.01-0.01) | 0.10 (0.07-0.16) | 0.04 (0.03-0.05) | 0.28 (0.18-0.45) | |
| IgM | 0.48 (0.38-0.59) | 1.16 (0.88-1.52) | 1.11 (0.87-1.42) | 2.07 (1.59-2.70) | |
a
The levels of antibodies against pneumococcal serotypes 4, 14, and 23F were quantified on days 0, 6 or 7, 56, and 62 or 63 after vaccination by ELISA. The 95% confidence intervals are given in parentheses.
b
These values represent a significant (P ≤ 0.0001) rise in the GMC above that from the baseline following the first dose of conjugate at day 0 and the second dose at day 56.