TABLE 2.
Performance of the first p24 assay on DBS from 6-week-old infants and from children between 6 weeks and 6 years of age
| Assay material | 6-wk-old infants
|
Children >6 wk and <6 yr
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of children
|
Positive predictive value (%)d | Negative predictive value (%)d | No. of children
|
Positive predictive value (%)d | Negative predictive value (%)d | |||||
| Total | With false-positive results | With false-negative results | Total | With false-positive results | With false-negative results | |||||
| Grade 1 paper | ||||||||||
| Without desiccant | 75 | 0 | 1a | 100 (64.6, 100) | 98.6 (92.2, 99.7) | 49 | 0 | 1c | 100 (92.7, 100) | 0 (0, 79.3) |
| With desiccant | 72 | 0 | 0 | 100 (64.6, 100) | 100 (94.4, 100) | 49 | 0 | 2a,c | 100 (92.7, 100) | 0 (0, 65.8) |
| 903 card | ||||||||||
| Without desiccant | 75 | 0 | 2a,b | 100 (64.6, 100) | 97.1 (90.2, 99.2) | 50 | 0 | 0 | 100 (92.9, 100) | |
| With desiccant | 72 | 0 | 0 | 100 (64.6, 100) | 100 (94.4, 100) | 49 | 0 | 1a | 100 (92.7, 100) | 0 (0, 79.3) |
a
False-negative p24 result on DBS on both filter paper types from the same child.
b
False-negative result on DBS on 903 card but not on grade 1 paper from the same child.
c
False-negative result on DBS on grade 1 paper but not on 903 card from the same child.
d
Values in parentheses are 95% confidence intervals.