TABLE 1.
Comparative in vitro susceptibilities of more than 10,000 clinical isolates of Candida species to fluconazole, voriconazole, and posaconazole determined by CLSI methods
| Species | Antifungal agent | No. of isolates tested | MIC (μg/ml)
|
% S | % R | ||
|---|---|---|---|---|---|---|---|
| Range | 50% of isolates | 90% of isolates | |||||
| C. albicans | Fluconazole | 5,827 | 0.12->128 | 0.25 | 0.5 | 99.3 | 0.1 |
| Voriconazole | 5,826 | 0.007-4 | 0.007 | 0.015 | 99.9 | <0.1 | |
| Posaconazole | 5,827 | 0.007-2 | 0.015 | 0.06 | 99.9 | 0.0 | |
| C. parapsilosis | Fluconazole | 1,542 | 0.12->128 | 0.5 | 2.0 | 96.2 | 0.6 |
| Voriconazole | 1,541 | 0.007-8 | 0.015 | 0.06 | 99.6 | 0.1 | |
| Posaconazole | 1,542 | 0.007-1 | 0.06 | 0.12 | 100 | 0.0 | |
| C. glabrata | Fluconazole | 1,517 | 0.25->128 | 8.0 | 32 | 53.1 | 9.6 |
| Voriconazole | 1,516 | 0.007-8 | 0.25 | 1.0 | 91.1 | 5.7 | |
| Posaconazole | 1,517 | 0.03->8 | 1.0 | 2.0 | 79.6 | 8.3 | |
| C. tropicalis | Fluconazole | 1,198 | 0.12-128 | 0.5 | 2.0 | 99.2 | 0.2 |
| Voriconazole | 1,197 | 0.007-8 | 0.03 | 0.06 | 99.8 | <0.1 | |
| Posaconazole | 1,198 | 0.015-2 | 0.06 | 0.12 | 99.9 | 0.0 | |
| C. krusei | Fluconazole | 305 | 8->128 | 32 | 64 | 1.3 | 34.1 |
| Voriconazole | 305 | 0.07-4 | 0.25 | 0.5 | 99.7 | 0.3 | |
| Posaconazole | 305 | 0.03-4 | 0.25 | 1.0 | 99.0 | 0.3 | |
| C. guilliermondii | Fluconazole | 138 | 0.5-32 | 4.0 | 8.0 | 92.8 | 0.0 |
| Voriconazole | 138 | 0.015-2 | 0.06 | 0.12 | 99.3 | 0.0 | |
| Posaconazole | 138 | 0.015-2 | 0.25 | 0.5 | 97.1 | 0.0 | |
| C. lusitaniae | Fluconazole | 133 | 0.12-64 | 0.5 | 1.0 | 97.7 | 1.5 |
| Voriconazole | 133 | 0.007-1 | 0.007 | 0.015 | 100 | 0.0 | |
| Posaconazole | 133 | 0.015-1 | 0.03 | 0.12 | 100 | 0.0 | |
| C. kefyr | Fluconazole | 51 | 0.12-1 | 0.25 | 1.0 | 100 | 0 |
| Voriconazole | 51 | 0.007-0.06 | 0.007 | 0.015 | 100 | 0.0 | |
| Posaconazole | 51 | 0.015-0.5 | 0.06 | 0.25 | 100 | 0.0 | |
| C. pelliculosa | Fluconazole | 31 | 1-8 | 4.0 | 8.0 | 100 | 0.0 |
| Voriconazole | 31 | 0.03-0.5 | 0.12 | 0.25 | 100 | 0.0 | |
| Posaconazole | 31 | 0.25-4 | 1.0 | 2.0 | 58.1 | 6.5 | |
| C. famata | Fluconazole | 19 | 0.5-16 | 2.0 | 8.0 | 94.7 | 0.0 |
| Voriconazole | 19 | 0.007-1 | 0.06 | 0.25 | 100 | 0.0 | |
| Posaconazole | 19 | 0.03-2 | 0.25 | 1.0 | 94.7 | 0.0 | |
| C. rugosa | Fluconazole | 13 | 0.5-16 | 4.0 | 16 | 61.5 | 0.0 |
| Voriconazole | 13 | 0.015-0.25 | 0.06 | 0.25 | 100 | 0.0 | |
| Posaconazole | 13 | 0.03-0.5 | 0.06 | 0.25 | 100 | 0.0 | |
| C. dubliniensis | Fluconazole | 12 | 0.12-8 | 0.25 | 0.25 | 100 | 0.0 |
| Voriconazole | 12 | 0.007-0.03 | 0.007 | 0.03 | 100 | 0.0 | |
| Posaconazole | 12 | 0.015-0.12 | 0.03 | 0.06 | 100 | 0.0 | |
| C. lipolytica | Fluconazole | 12 | 1-64 | 4.0 | 8.0 | 91.7 | 8.3 |
| Voriconazole | 12 | 0.015-1 | 0.06 | 0.12 | 100 | 0.0 | |
| Posaconazole | 12 | 0.12-4 | 0.5 | 1.0 | 91.7 | 8.3 | |
| C. zeylanoides | Fluconazole | 8 | 0.12->128 | 0.5 | 87.5 | 12.5 | |
| Voriconazole | 8 | 0.007-4 | 0.007 | 87.5 | 12.5 | ||
| Posaconazole | 8 | 0.007-2 | 0.06 | 87.5 | 0.0 | ||
| All Candida | Fluconazole | 10,807 | 012->128 | 0.25 | 16 | 89.5 | 2.5 |
| Voriconazole | 10,803 | 0.007-8 | 0.015 | 0.25 | 98.6 | 0.9 | |
| Posaconazole | 10,807 | 0.007->8 | 0.03 | 1.0 | 96.9 | 1.2 | |