TABLE 4.
In vitro activities of amphotericin B, flucytosine, and the echinocandins against bloodstream isolates of Candida krusei
| Antifungal agenta | No. of isolates tested | Cumulative % of C. krusei isolates inhibited at a MIC (μg/ml) of:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | ||
| Amphotericin B | 304 | 4 | 4 | 5 | 7 | 24 | 51 | 85 | 98 | 99 | 100 | ||
| Flucytosine | 254 | 1 | 1 | 1 | 1 | 2 | 5 | 8 | 26 | 93 | 99 | 99 | |
| Anidulafungin | 121 | 49 | 92 | 99 | 99 | 100 | |||||||
| Caspofungin | 300 | 1 | 40 | 69 | 90 | 98 | 99 | 100 | |||||
| Micafungin | 102 | 12 | 84 | 99 | 100 | ||||||||
a
Amphotericin B MICs were determined by Etest after 24 h of incubation. Echinocandin MICs were determined using RPMI 1640 broth with 24 h of incubation and an end point criterion of a prominent reduction in growth (MIC-2).