TABLE 3.
Presence of putative virulence genes in S. aureus isolates from patients with cSSSI in the United States
| Gene | No. of isolates positive for the gene (% of total [n = 56]) | Methicillin resistance phenotype (no. of isolates [%])
|
P valuea | |
|---|---|---|---|---|
| MRSA (n = 44) | MSSA (n= 12) | |||
| Adhesins | ||||
| fnbA | 50 (89) | 40 (91) | 10 (83) | 0.60 |
| clfA | 56 (100) | 44 (100) | 12 (100) | NA |
| clfB | 56 (100) | 44 (100) | 12 (100) | NA |
| cna | 33 (59) | 24 (55) | 9 (75) | 0.32 |
| spa | 56 (100) | 44 (100) | 12 (100) | NA |
| sdrC | 49 (88) | 41 (93) | 8 (67) | 0.03* |
| sdrD | 53 (95) | 44 (100) | 9 (75) | <0.01** |
| sdrE | 49 (88) | 42 (95) | 7 (58) | <0.01** |
| bbp | 56 (100) | 44 (100) | 12 (100) | NA |
| ebps | 56 (100) | 44 (100) | 12 (100) | NA |
| map/eap | 45 (80) | 38 (86) | 7 (58) | 0.05* |
| fnbB | 53 (95) | 43 (98) | 10 (83) | 0.11* |
| Toxins | ||||
| eta | 35 (63) | 32 (73) | 3 (25) | <0.01** |
| etb | 22 (39) | 22 (50) | 0 (0) | <0.01** |
| tst | 36 (64) | 32 (73) | 4 (33) | 0.02* |
| sea | 34 (61) | 30 (68) | 4 (33) | 0.04* |
| seb | 8 (14) | 7 (16) | 1 (8) | 0.67 |
| sec | 13 (23) | 10 (23) | 3 (25) | 1 |
| sed | 19 (41) | 18 (41) | 1 (8) | 0.04* |
| see | 41 (73) | 41 (93) | 0 (0) | <0.01** |
| seg | 25 (45) | 17 (39) | 8 (67) | 0.11* |
| seh | 26 (46) | 22 (50) | 4 (33) | 0.35 |
| sei | 48 (86) | 38 (86) | 10 (83) | 1 |
| sej | 50 (89) | 41 (93) | 9 (75) | 0.11* |
| pvl | 48 (86) | 39 (89) | 9 (75) | 0.35 |
| hlg | 56 (100) | 44 (100) | 12 (100) | NA |
| agr group I vs all others | 47 (84) | 39 (89) | 8 (67) | 0.09* |
| Other genes | ||||
| efb | 56 (100) | 44 (100) | 12 (100) | NA |
| icaA | 56 (100) | 44 (100) | 12 (100) | NA |
| chp | 55 (98) | 43 (98) | 12 (100) | 1 |
| V8 | 51 (91) | 42 (95) | 9 (75) | 0.06* |
a
*, statistically significant result with FDR of 20%; **, statistically significant result with FDR of 5%. NA, not applicable.