TABLE 5.
Association of putative virulence genes with clinical outcome among S. aureus isolates from 90 patients with skin and soft tissue infection
| Gene | No. of patients (%) with the outcome:
|
P valuea | |
|---|---|---|---|
| Cure (n = 84) | Failure or indeterminate (n = 6) | ||
| Adhesins | |||
| fnbA | 77 (92) | 4 (67) | 0.11 |
| clfA | 84 (100) | 6 (100) | NA |
| clfB | 81 (96) | 6 (100) | 1 |
| cna | 59 (70) | 5 (83) | 0.67 |
| spa | 84 (100) | 6 (100) | NA |
| sdrC | 66 (79) | 6 (100) | 0.34 |
| sdrD | 81 (96) | 6 (100) | 1 |
| sdrE | 68 (81) | 4 (67) | 0.60 |
| bbp | 81 (96) | 6 (100) | 1 |
| ebps | 84 (100) | 6 (100) | NA |
| map/eap | 55 (65) | 3 (50) | 0.66 |
| fnbB | 75 (89) | 5 (83) | 1 |
| Toxins | |||
| eta | 47 (56) | 4 (67) | 0.69 |
| etb | 22 (26) | 1 (17) | 0.69 |
| tst | 49 (58) | 4 (67) | 1 |
| sea | 59 (70) | 4 (67) | 1 |
| seb | 19 (23) | 0 (0) | 0.34 |
| sec | 27 (32) | 1 (17) | 0.66 |
| sed | 25 (30) | 3 (50) | 0.37 |
| see | 48 (57) | 4 (67) | 0.70 |
| seg | 47 (56) | 6 (100) | 0.08 |
| seh | 45 (54) | 2 (33) | 0.42 |
| sei | 77 (92) | 5 (83) | 1 |
| sej | 78 (93) | 4 (67) | 0.09 |
| pvl | 79 (94) | 3 (50) | 0.01* |
| hlg | 84 (100) | 6 (100) | NA |
| agr group I vs all others | 63 (75) | 5 (83) | 1 |
| Others | |||
| efb | 84 (100) | 6 (100) | NA |
| icaA | 84 (100) | 6 (100) | NA |
| chp | 83 (99) | 6 (100) | 1 |
| V8 | 75 (89) | 5 (83) | 1 |
a
*, statistically significant result with FDR of 20%.