TABLE 2.

Genotype and subtype-specific residue substitutions in the deduced F protein sequence

Genotype, subtype, and strain(s)	Subtype-specific residue substitution in the deduced F protein sequence for consensus residue:
	4 K	9 I	16 I	17 T	20 M	22 I	28 P	32 L	52 I	69 M	82 E	101 R	104 G	107 S	121 Ic	124 S	176 A	192 N	195 R	272 Y	288 N	314 F	341 S	385 A	396 I	482 A	494 R	516 A	520 V
Ia	R	-b	T	V	A	E	-	-	-	L	-	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	I	-
II	R/-	N	A/T	I/V	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	I/V	I/-
SBZ/02	-	N	A	I	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	I	I
SY/03	R	N	A	I	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	I	I
JS05/03	-	N	T	I	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	V	I
TEX/48	R	N	T	V	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	T	-	T	T	M	E	K	I	-
SRZ/03	R	N	T	V	A	V	-	I	-	L	D	-	E	T	-	G	-	K	Q	N	-	Y	-	-	-	-	-	-	-
VIId	R/-	V/-	T	V/I	A	A	L	-	-	-	-	-	E	T	-	-	-	-	Q	N	T	-	T	T	M	E	K	I	-
Aus-Vice	R	-	T	I	A	A	L	-	-	-	-	-	E	T	-	-	-	-	Q	N	T		T	T	M	E	K	I	-
SBD/02	-	V	T	V	A	A	L	-	-	-	-	-	E	T	-	-	-	-	Q	N	T	-	T	T	M	E	K	I	-
IV	R	-	-	I	V	T	L	-	-	-	-	-	E	T	-	-	-	-	Q	N	T	-	T	-	M	E	-	V	-
V	R/-	L/V/-	T/L/-	I/-	T/A/-	T/-	L/-	-	-	-	-	-	-	T	-	-	-	-	Q/-	N	-	-	-	-	M	E/-	K/N	V/L	I/-
VII	-	-	-	-	T	-	L	-	-	-	-	-	-	T	V	-	-	-	-	-	-	-	-	-	M	-	-	V	-
VI	T/-	-	-	-	T/-	-	L/-	-	-	-	-	-	-	-	-	-	-	-	-	N	-	L/-	T/-	-	M/-	-	K/-	T/-	I/-
PB01/96	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	N	-	-	T	-	-	-	-	-	I
VIIa	E/-	V/-	-	-	-	-	L	-	-	-	-	K	-	-	V	-	S	-	-	-	-	-	-	-	-	-	K/-	-	-
VIIb	-	-	-	-	-	-	S	-	-	-	-	-	-	-	V	-	-	-	-	H	T	-	-	-	-	-	-	-	-
VIIc	R/T/-	-	-	-	I/-	-	L/-	-	V/-	-	-	K	-	-	V	-	S	-	-	-	-	Y	-	-	-	-	-	-	-
SWS/03	-	-	-	-	I	-	-	-	-	-	-	K	-	-	V	-	S	-	-	-	-	Y	-	-	-	-	-	-	-
VIId	T/-	-	V/-	-	-	M/-	S/L/-	-	V	-	-	K	-	-	I/V	-	S/-	K/-	Q/-	N/-	-	Y	-	-	-	-	K/G/-	-	G/-
SGM/01	-	-	-	-	-	-	-	-	V	-	-	K	-	-	V	-	S	-	-	-	-	Y	-	-	-	-	-	-	G

^aData for genotypes I, II, III, IV, V, VI, VII (VIIa and VIIb), and VIII were derived from references 15 and 28 and from this study.

^bA dash indicates genetic identity with the consensus residue.

^cThe majority of the isolates or strains show V-for-I substitutions, while a few isolates or strains exhibit no change.

^dFor the representative strains used in this study, the deduced amino acid sequences and alignments were conducted using the MegAlign program (MegAlign 4.00) in the Lasergene package (DNAStar Inc., Madison, WI).

^eNDV strain Australia-Victoria.