FIG. 1.

Divergence of modern M. tuberculosis strains into the three PGGs, based on characteristic SNPs and the loss of TbD1. The SNPs shown in this diagram were selected for inclusion in the M. tuberculosis-specific MLPA assay described in this study. The diagram gives the expected MLPA products for each subgroup. The subdivision of Beijing strains is not officially recognized or correlated to the main genotyping methods but is done here simply to illustrate the different subtypes that can be distinguished on the basis of the mutations in these genes. The data are abstracted from references 26 and 37.