TABLE 6.
Nucleotide polymorphisms and amino acid substitutions in C. dubliniensis locid
| Gene fragment | Nucleotide position showing polymorphisma | Triplet polymorphismb | Amino acidsc | Corresponding codon in C. albicans | Corresponding amino acid residue in C. albicans |
|---|---|---|---|---|---|
| CdAAT1a | 2 | (T/C)TG | L/L | TTG | L |
| CdAAT1b | 105 | A(T/A)T | I/N | ATC | I |
| 114 | TC(A/T) | S/S | TCA | S | |
| 121 | (G/A)AA | E/K | GAA | E | |
| 129 | TC(T/G) | S/S | TCT | S | |
| CdACC1 | 128 | TT(T/C) | F/F | TTC | F |
| 313 | T(T/C)G | L/S | CTG | L | |
| 390 | AA(A/T) | K/N | AAA | K | |
| CdADP1 | 31 | AT(C/T) | I/I | ATT | I |
| 214 | AG(C/T) | S/S | AGT | S | |
| 234 | G(A/G)G | E/G | GAG | E | |
| 331 | TG(T/C) | C/C | TGT | C | |
| 421 | TC(G/T) | S/S | TCA | S | |
| CdGLN4 | 104 | GA(A/T) | E/D | GTA | V |
| 141 | AA(T/C) | N/N | AAA | K | |
| 147 | GA(T/C) | D/D | GAC | D | |
| 244 | (A/G)TT | I/V | ATT | I | |
| CdMPIb | 101 | A(G/A)A | R/K | AGA | R |
| 375 | GC(A/G) | A/A | GCA | A | |
| CdRPN2 | 127 | TC(C/A) | S/S | TCC | S |
| 136 | GC(C/T) | A/A | GCC | A | |
| 298 | GC(T/C) | A/A | GCA | A | |
| CdSYA1 | 82 | AA(C/T) | N/N | AAT | N |
| 148 | TT(A/G) | L/L | TTA | L | |
| 186 | AA(T/C) | N/N | AAT | N | |
| 203 | G(T/C)T | V/A | GTT | V | |
| 383 | (T/G)CT | S/A | GCT | A | |
| CdVPS13 | 397* | AA(A/G) | K/K | AAG | K |
| 402† | T(G/C)G | W/S | TGG | W | |
| exCdVPS13 | 45 | GA(G/C) | E/D | GAC | D |
| 654* | AA(A/G) | K/K | AAG | K | |
| 659† | T(G/C)G | W/S | TGG | W | |
| CdZWF1b | 1‡ | AC(C/T) | T/T | AAA | K |
| 28§ | AC(G/A) | T/T | ACC | T | |
| 265¶ | AA(G/A) | K/K | AAA | K | |
| 299‖ | (G/T)AT | D/Y | GAT | D | |
| 334# | AA(A/G) | K/K | AAA | K | |
| exCdZWF1b | 78‡ | AC(C/T) | T/T | AAA | K |
| 105§ | AC(G/A) | T/T | ACC | T | |
| 342¶ | AA(G/A) | K/K | AAA | K | |
| 376‖ | (G/T)AT | D/Y | GAT | D | |
| 411# | AA(A/G) | K/K | AAA | K | |
| 573 | TA(T/C) | Y/Y | TAT | Y | |
| 588 | TC(A/T) | S/S | TCA | S |
a
Nucleotide positions refer to the positions in the analyzed fragment only.
b
Position of the polymorphism relative to its codon.
c
Amino acid resulting from the codon both before and after polymorphism.
d
The nucleotide sites shown in bold typeface and underlined denote the only common nucleotide sites that display polymorphism in both C. albicans and C. dubliniensis. Identical polymorphic sites in both of the extended gene segments analyzed and in the shorter sequences that were based on the C. albicans scheme lengths are marked with the same symbols.