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. 2007 Dec 7;7(2):339–349. doi: 10.1128/EC.00355-07

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Copyright © 2008, American Society for Microbiology

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FIG. 2. — Predicted domains of A. nidulans and A. fumigatus Dicer and Argonaute proteins. The predicted sequences of A. nidulans and A. fumigatus DclB, DclA and PpdB were used to search the National Center for Biotechnology Information conserved domain database for domain identification. The truncated nature of A. nidulans dclA and ppdB is revealed by comparison to their A. fumigatus orthologs. The A. nidulans group Q Argonaute, RsdA, was characterized in a previous study (30). An MPH1 domain overlaps the DEAD and Hel C domains in both A. fumigatus Dicer proteins and A. nidulans DclB (not shown). Dicer domains: DEAD-like helicase (pfam00270, smart00487), horizontal bars; Helicase C (cd00079), diagonal bars; Duf283 (pfam03368), vertical bars; RNase III (cd00593), black boxes; MPH1 (cog1111.1). Argonaute domains: PAZ (cd02846), dark gray boxes; Piwi (pfam02171), diagonal bars.