TABLE 1.

Structure of sampangine and the in vitro antifungal activity of sampangine compared to that of amphotericin B^a

^aBroth microdilution assays were performed according to CLSI guidelines (52, 53). The media used were RPMI for A. fumigatus and Candida spp. and Sabouraud dextrose for C. neoformans. The temperature of incubation was 37°C for Candida spp. and 30°C for C. neoformans and A. fumigatus. Numbers are in micrograms/milliliter and are average values from duplicate experiments. The strains used were C. albicans ATCC 90028, C. glabrata ATCC 90030, C. kruseii ATCC 6258, A. fumigatus ATCC 90906, and C. neoformans ATCC 90113.