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. 2002 Apr;119(4):297–312. doi: 10.1085/jgp.20028501

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Copyright © 2002, The Rockefeller University Press

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Figure 9. — Stimulation of I_P in canine cardiac myocytes. Stimulation of I_P by low concentrations of DHO (10⁻⁹, 10⁻⁸, and 10⁻⁷ M) and the inhibition of I_P by a high concentration of DHO (10⁻⁴ M) were observed in canine atrial (A), ventricular epicardial (B), and ventricular endocardial (C) cells. The dotted lines indicate the holding current in the absence of DHO. Similar results were obtained from at least five cells from each region.