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. 2002 Apr;119(4):297–312. doi: 10.1085/jgp.20028501

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Adrenergic modulation of I_P in guinea pig ventricular myocytes suggests the α₂-isoform and not the α₁-isoform is involved in stimulation of I_P by low [DHO]. (A) A typical record of holding current in an experiment showing the effect of β-adrenergic activation with ISO on stimulation of I_P by 10 nM DHO. The vertical bar labeled with ΔI_P indicates the magnitude of the stimulation of I_P. The large increase in holding current in the presence of ISO is mainly due to the activation of the Cl⁻ conductance (Harvey and Hume, 1989; Bahinski et al., 1989). (B) Summary of the results from a total of five cells. ΔI_P was normalized by its value in control conditions. The normalized ΔI_P in the presence of ISO was 0.98 ± 0.04 (SD), suggesting that ISO had no effect on the stimulation (P = 0.51). (C) A typical record of holding current in an experiment showing the effect of α-adrenergic activation (NE and PROP) on ΔI_P. (D) Summary of the results from a total of five cells. The normalized ΔI_P in the presence of α-activation was 1.54 ± 0.11 (SD), suggesting that α activation enhanced the stimulation of I_P (P = 0.008).