Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2002 Apr;119(4):297–312. doi: 10.1085/jgp.20028501

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2002, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — [K⁺]_o modulation of I_P in guinea pig ventricular myocytes suggests the α₂-isoform and not the α₁-isoform is involved in stimulation of I_P by low [DHO]. (A) An original record of holding current showing the protocol for observing stimulation of I_P by low [DHO] and inhibition of I_P by high [DHO] in 4 and 8 mM [K⁺]_o. In this cell, when [K⁺]_o was 4 mM, the stimulation of I_P was 26 pA and the inhibition was 71 pA. When [K⁺]_o was increased to 8 mM, the stimulation of I_P was 27 pA and the inhibition was 96 pA. Thus activity of the α₁-isoform increased, but the stimulation did not. (B) Average results from five cells. In each cell, the stimulation by 10 nM DHO and the inhibition by 1 mM DHO were recorded in 4 and 8 mM [K⁺]_o, and then the ratio of the stimulation of I_P (1.04 ± 0.08, P = 0.31) at the two [K⁺]_o and the ratio of the total I_P (1.39 ± 0.20, P = 0.029) at the two [K⁺]_o were recorded and averaged.