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. 2002 Apr;119(4):297–312. doi: 10.1085/jgp.20028501

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — RNase protection assays indicate the lack of α₂-isoform in guinea pig ventricular myocytes that lacked the stimulation of I_P. mRNA for the α₁-, α₂- and α₃-isoforms of the Na/K pump are abundantly expressed in guinea pig brain. In contrast, the α₁-isoform is the dominant transcript in guinea pig ventricle. The α₂-isoform is present at very low levels, just 6 ± 4% (SD) of the total Na/K pump mRNA based on quantification from three different samples (compared with 18% in normal samples). No α₃-isoform mRNA was detected from any guinea pig heart sample.