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(A) Model of pheromone response and control in a donor cell. cCF10 is imported into the cytoplasm, where it interacts with PrgX, causing derepression of PQ and subsequent induction of downstream conjugation genes. PrgY reduces endogenous cCF10, and iCF10 neutralizes remaining cCF10. (B) Predicted proteolytic processing of cCF10. cCF10 is processed from CcfA in several steps. SPII, signal peptidase II; Eep, membrane protease; C.P., carboxy peptidase. Triangles indicate cleavage sites.
