Table 1.
Oral suppression of EAE in rats
| Fed Ag | Incidence | Mean max. score | Mean onset, days | Suppression of EAE, %
|
|
|---|---|---|---|---|---|
| Incidence | Score | ||||
| PBS, control | 7/9 | 1.05 ± 0.7 | 11.2 | ||
| Cop 1, 0.5 mg | 5/9 | 0.61 ± 0.6 | 11.6 | 29 | 42 |
| Cop 1, 1 mg | 3/9 | 0.33 ± 0.55 (P = 0.01) | 13.0 | 57 | 69 |
| Cop 1, 2 mg | 4/9 | 0.44 ± 0.5 | 11.0 | 43 | 58 |
| PBS, control | 27/28 | 1.8 ± 0.5 | 11.9 | ||
| MBP, 1 mg | 10/17 (P = 0.0026) | 0.9 ± 0.5 (P < 0.00001) | 11.4 | 39 | 50 |
| Cop 1, 1 mg | 13/28 (P = 0.00005) | 0.78 ± 0.4 (P < 0.00001) | 12.6 | 52 | 57 |
Each incidence figure represents the cumulative results of 2–5 individual experiments.