Table 1.
Incidence of diabetes after immunization with influenza virus (%)
| Virus | Age | Time after infection, days | Diabetes | Insulitis | Peri-Insulitis | Pristine |
|---|---|---|---|---|---|---|
| PR8 | 1 week | 9 | 0% | 0% | 0% | 100% |
| Vacc-WT | 7 | 0% | ND | ND | ND | |
| Vacc-KdHA | 7 | 100% | ND | ND | ND | |
| PR8 | 1 week | 9 | 100% | 100% | 0% | 0% |
| ” | 2 weeks | 9 | 50% | 100% | 0% | 0% |
| 21 | 0% | 36% | 24% | 40% | ||
| ” | 4 weeks | 9 | 50% | 84% | 14% | 2% |
| 21 | 0% | 11% | 21% | 68% | ||
| ” | 8 weeks | 9 | 0% | 0% | 27% | 73% |
| 21 | 0% | 0% | 10% | 90% |
Groups of between 6 and 8 InsHA mice of various ages were immunized with virus as shown. Data show the incidence of diabetes and degree of insulitis observed in pancreata take from immunized mice. Data are expressed as the percentage of the total number of islets examined from all mice in each group, 9 days and 21 days later. Mice were considered diabetic if their blood glucose was above 300 mg/dl. ND, not determined.