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. 2008 Feb 15;22(4):463–475. doi: 10.1101/gad.1627208

Figure 1.

Figure 1.

Deletion of Rb in the erythroid compartment causes a stable anemia. (A) qRT–PCR of RNA from sorted CD71high/Ter-119high BM cells from EpoR-GFPcre/+; pRbfl/+ (pRbΔ/+), and EpoR-GFPcre/+; pRbfl/fl (pRbΔ/Δ) 8- to 12-wk-old animals (n ≥ 3). (**) P < 0.01. (B) Representative PB smears viewed at 600× magnification. Howell-Jolly bodies are seen in adult pRbΔ/Δ mice (arrows). (C–E) RBC counts in EpoR-GFPcre/+ animals (C), LysM-Cre animals (D), and EpoR-GFPcre and LysM-Cre animals (E) at multiple time points during life. (*) P < 0.05; (**) P < 0.01. (F) RBC counts in Mx1-Cre adult animals following somatic deletion. (*) P < 0.05; (**) P < 0.01. (G,H) Reticulocyte percentages (G) and serum erythropoietin levels (H) in EpoR-GFPcre/+ animals (n ≥ 4).