Fig. 5.

Intraperitoneal glucose tolerance tests (IPGTTs) in BESTO transgenic and control mice fed a Western-style high-fat diet (HFD). (A) IPGTTs were conducted in male and female BESTO transgenic (closed circles) and control (open circles) mice following 12 weeks on a HFD. Following a 15 h fast, 2 g of 50% glucose (w/v) per kg body weight was injected intraperitoneally, and blood glucose values were assessed at 0, 15, 30, 60, and 120 min post-injection (n = 9–14). (B) Plasma insulin levels in male and female transgenic mice (black bars) and controls (white bars) were measured at the 0, 15, and 30 min time points during the IPGTTs shown in (A). All results are expressed as mean ± standard error. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.