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. Author manuscript; available in PMC: 2008 Feb 11.
Published in final edited form as: Aging Cell. 2007 Nov 14;7(1):78–88. doi: 10.1111/j.1474-9726.2007.00355.x

Fig. 6.

Fig. 6

The effect of NMN administration on IPGTTs and plasma insulin levels in aged BESTO and control female mice. (A) NAD content in 100 cultured pancreatic islets isolated from young (Y, 5 months old) and old (O, 19 months old) BESTO mice. The measurements were conducted in duplicate or triplicate of primary islets pooled from three individual mice. (B) Plasma NMN levels in young (Y, 5 months old) and old (O, 19 months old) BESTO mice. The measurements were conducted with four individual mice for each sex and age. (C) IPGTTs were conducted in 20-month-old female BESTO transgenic mice (closed circles) and controls (open circles) from line 431-4 after mice were injected with PBS or NMN (500 mg kg−1 body weight) and fasted for 14 h (n = 10–15). (D) Plasma insulin levels were measured at 0 and 30 min post-glucose injection. #P ≤ 0.05; §P ≤ 0.01, compared to insulin levels 30 min after glucose injection in PBS-injected aged BESTO and control mice. All results are expressed as mean ± standard error. *P ≤ 0.05; ***P ≤ 0.001.