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. 1999 Mar 30;96(7):3870–3875. doi: 10.1073/pnas.96.7.3870

Figure 6.

Figure 6

2B4L expression inhibits redirected lysis by NKR-P1A but not antibody-dependent cellular cytotoxicity in RNK-16 cells. (A) A redirected lysis assay using P815 targets is shown. Various RNK-16 transfectants were used at an effector-to-target ratio of 100:1. Where indicated, effectors were preincubated with anti-rat NKR-P1A (3.2.3 antibody) or with anti-2B4 antibody as described in Fig. 2. As shown for Fig. 2, baseline lysis of P815 targets by all transfectants was consistently <2%. (B) An antibody-dependent cellular cytotoxicity assay using P815 targets is shown. Various RNK-16 transfectants were used as effectors as described for Fig. 6. Where indicated, effectors were preincubated with anti-P815 (rabbit polyclonal antisera) or anti-2B4 antibody as described for Fig. 2. As shown for Fig. 2, baseline lysis of P815 targets by all transfectants was consistently <2%.