Table 4.

Association between ESR SNPs and obesity in samples 1 and 2^a

Gene	SNP	Controls (n)			Cases (n)			Allele Frequency		Heterozygous		Homozygous		Recessive model		Armitage's trend test
		22b	21	11	22	21	11	[2]<-> [1]c	P value	[22]<-> [12]	P value	[22]<-> [11]	P value	[11+12]<-> [22]	P value	OR	P value
Sample 1
ESR1	rs2813544	10	134	255	33	242	408	0.82 [0.66–1.02]	0,08	0.55 [0.26–1.14]	0,11	0.48 [0.24–1.00]	0,05	0.51 [0.25–1.04]	0,06	0,79	0,07
	Women	8	114	213	29	194	339	0.83 [0.66–1.06]	0,13	0.47 [0.21–1.06]	0,06	0.44 [0.20–0.98]	0,04	0.45 [0.20–1.00]	0,04	0,79	0,13
	Men	2	20	42	4	48	69	0.77 [0.45–1.31]	0,33	1.20 [0.20–7.08]	0,84	0.82 [0.14–4.68]	0,82	0.94 [0.17–5.30]	0,95	0,78	0,31
ESR2	rs7154455	107	167	47	273	260	62	0.70 [0.57–0.85]	0,0003	0.61 [0.45–0.82]	0,001	0.52 [0.33–0.80]	0,003	0.59 [0.44–0.78]	0,0002	0,7	0,0003
	Women	84	144	43	223	219	45	0.63 [0.51–0.78]	0,00003	0.57 [0.41–0.80]	0,0008	0.39 [0.24–0.64]	0,0001	0.53 [0.39–0.73]	0,00007	0,62	0,00002
	Men	23	23	4	50	41	17	1.18 [0.71–1.97]	0,51	0.82 [0.40–1.67]	0,58	2.0 [0.59–6.46]	0,27	0.99 [0.50–1.94]	0,97	1,26	0,53
	rs3020450	177	163	44	353	237	59	0.78 [0.64–0.94]	0,01	0.73 [0.56–0.95]	0,02	0.67 [0.44–1.03]	0,07	0.72 [0.56–0.92]	0,01	0,8	0,01
	Women	147	139	41	288	202	42	0.72 [0.58–0.89]	0,002	0.74 [0.55–1.00]	0,05	0.52 [0.33–0.84]	0,007	0.69 [0.52–0.91]	0,009	0,73	0,003
	Men	30	24	3	65	35	17	1.17 [0.71–1.94]	0,54	0.67 [0.34–1.32]	0,25	2.61 [0.71–9.61]	0,14	0.89 [0.47–1.68]	0,72	1,32	0,57
ESR2	Women
	rs1152582	54	171	110	127	274	161	0.80 [0.66–0.98]	0,03	0.68 [0.47–1.00]	0,04	0.62 [0.42–0.93]	0,01	0.66 [0.46–0.94]	0,02	0,8	0,03
	rs1271572	59	172	104	130	281	151	0.82 [0.68–1.00]	0,05	0.74 [0.52–1.06]	0,1	0.66 [0.44–1.00]	0,04	0.71 [0.50–1.00]	0,05	0,82	0,04
	rs1269056	53	175	107	127	275	158	0.81 [0.66–0.98]	0,03	0.66 [0.45–0.95]	0,03	0.62 [0.41–0.92]	0,02	0.64 [0.45–0.91]	0,01	0,8	0,03
ESR2	Men
	rs4986938	4	30	30	20	59	45	0.64 [0.40–1.00]	0,05	0.39 [0.12–1.26]	0,11	0.30 [0.09–0.96]	0,04	0.35 [0.11–1.06]	0,05	0,6	0,05
Sample 2
ESR2	rs3020450	326	245	41	410	332	60	1.08 [0.91–1.27]	0,39	1.08 [0.86–1.34]	0,51	1.16 [0.76–1.78]	0,48	1.09 [0.88–1.34]	0,42	1.08	0,38
	Women	273	216	35	346	282	53	1.06 [0.89–1.27]	0,42	1.03 [0.81–1.31]	0,81	1.20 [0.76–1.88]	0,44	1.05 [0.84–1.32]	0,65	1.07	0,51
	Men	53	29	6	64	50	7	1.18 [0.75–1.86]	0,46	1.42 [0.80–2.56]	0,23	0.97 [0.31–3.05]	0,95	1.35 [0.77–2.35]	0,29	1.11	0,46
	rs7154455	318	248	46	399	341	63	1.06 [0.90–1.26]	0,45	1.10 [0.88–1.37]	0,42	1.09 [0.73–1.64]	0,67	1.09 [0.89–1.35]	0,40	1.06	0,44
	Women	268	216	40	337	287	57	1.06 [0.89–1.27]	0,52	1.06 [0.83–1.34]	0,65	1.13 [0.73–1.75]	0,57	1.07 [0.85–1.34]	0,57	1.06	0,52
	Men	50	32	6	62	54	6	1.11 [0.71–1.73]	0,64	1.36 [0.77–2.42]	0,29	0.81 [0.24–2.65]	0,72	1.27 [0.73–2.21]	0,74	1.05	0,63

a) Shown are SNPs with P value < 0.05 in at least one analysis.

b) 1 and 2 represent the two alleles of each SNP.

c) OR (95% confidence interval)