Fig. 4.
rVV encoding TRP-2 has a therapeutic effect on tumor-bearing mice. Mice were injected s.c. with 105 B16 melanoma cells. Five days later, they received a single i.v. inoculation of 5 × 106 PFU of an rVV encoding TRP-2 (rVV-trp-2). Untreated mice and mice injected with the same amount of mock virus (rVV) were used as negative controls. Results represent the sums of two independently performed experiments with five to six mice in each treatment group. The statistical analysis was performed according to the Mantel-Haenszel test (P = 0.04, no treatment versus rVV-trp-2; P = 0.001, rVV versus rVV-trp-2).