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Example of remote homologs retrieved by the ‘Domain similarity’ tool of SIMAP. When searching the query sequence in the Uniprot database, high E-values result from the low bitscores. Thus, these proteins show insufficient pairwise sequence homology to the query and would not be found by database searches that are typically restricted to a maximal E-value of 10. However, the similar domain architectures suggest a common ancestry of these proteins.
