Figure 2.

Example of a complex query: search for an alternative drug to Taxol, which adresses the same target Bcl-2, but is not metabolized by the cytochrome 2C8. Procedure: start to search for the targets and the metabolizing cytochromes of Taxol in the associated categories. The resulting lists contain among others the target Bcl-2 as well as the P450 cytochrome 2C8. Second, forward 2C8 and Bcl-2 into the query term box, combine them using the ‘NOT’ operator and submit the query. The resulting drug list contains two alternative drug candidates for Taxol (Docetaxel and Flupirtine).