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. Author manuscript; available in PMC: 2008 Feb 12.
Published in final edited form as: J Immunol. 1998 Nov 1;161(9):4563–4571.

FIGURE 4.

FIGURE 4

IFN-γ enhancement by CD40LT DNA is dependent on IL-12 and B7 costimulation. Mice were vaccinated in a manner similar to that described in Figure 1. In some groups, mice were treated with anti-IL-12 (1 mg), CTLA4Ig (100 μg), or L6Ig (100 μg) i.p. at the time of each vaccination. IFN-γ was assessed from spleen cells 2 wk after the second vaccination, as described in Figure 1. Data shown represent values averaged from four pooled mice. SEM was <10% in the experiment shown. *, p < 0.005 in comparing IFN-γ produced from mice vaccinated with β-gal DNA with or without CD40LT DNA and treated with anti-IL-12 or CTLA4Ig.