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. Author manuscript; available in PMC: 2008 Feb 12.
Published in final edited form as: J Immunol. 1998 Nov 1;161(9):4563–4571.

FIGURE 6.

FIGURE 6

CD40LT DNA enhancement of CTL activity is dependent both on B7 costimulation and on CD8. Mice were vaccinated in a manner similar to that described in Figure 4. CTL activity from splenocytes was assessed as described in Figure 3. In addition, anti-CD8 or anti-CD4 Ab was added at the time of the 51 Cr release assay. Data shown represent values averaged from four pooled mice with SEM for each E:T ratio. Statistical analysis was performed for E:T ratios of 100:1, 50:1, and 25:1. *, p < 0.05 in comparing CTL from mice vaccinated with β-gal DNA plus CD40LT DNA plus L6Ig with that from mice vaccinated with β-gal DNA alone. **, p < 0.05 in comparing CTL from mice vaccinated with β-gal DNA plus CD40LT DNA plus L6Ig plus anti-CD8 with that from mice vaccinated with β-gal DNA plus CD40LT DNA plus L6Ig.