Table 1.
Effect of modulators on net content of MDR transport substrates in cultured rat choroid plexus epithelial cells
| Radioprobe | GF120918
|
MK-571
|
||||||
|---|---|---|---|---|---|---|---|---|
| Basal
|
Apical
|
Basal
|
Apical
|
|||||
| − | + | − | + | − | + | − | + | |
| 99mTc-sestamibi | 0.85 ± 0.04 | 3.04 ± 0.15** | 0.93 ± 0.08 | 3.34 ± 0.07** | 1.39 ± 0.02 | 2.24 ± 0.21* | 2.14 ± 0.13 | 4.19 ± 0.19** |
| [3H]Taxol | 2.95 ± 0.19 | 4.5 ± 0.09* | 5.54 ± 0.05 | 7.13 ± 0.36* | ND | ND | ND | ND |
Data are presented as percentage of total activity added to basal or apical side (mean ± SEM of three determinations each). ND, not determined. ∗, P < 0.05; ∗∗, P < 0.001.