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AP-1 activity and cell transformation are inhibited in CSK wildtype cells. A, CSK−/− cells had an increased transforming ability with or without EGF (10 ng/ml) induction. B, CSK−/− cells had an increased AP-1 activity with or without EGF (10 ng/ml) induction. Significant differences were evaluated using the Student’s t test (*, p < 0.01). C, photomicroscopy of anchorage-independent growth of CSK+/+ and CSK−/− cells without EGF treatment.
