Figure 1.
JNK cascade activation occurs in spontaneous human SCC. A, immunoperoxidase staining of tissue microarrays of patient SCCs (n = 52). Samples were graded as strong, moderately strong, or negative, with representative histology shown: pJNK (brown) and nuclei (blue). Magnification, ×100. B, immunoperoxidase staining of 6-week-old skin grafts regenerated with keratinocytes expressing LacZ or Ras and IκBα for pJNK. Magnification, ×100.