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. 2007 Oct 22;7(1):92–100. doi: 10.1111/j.1601-183X.2007.00377.x

Figure 1. Tau pathology in aged THY-Tau22.

Figure 1

(a) AT8-ir in the DG in a 3-month-old THY-Tau22 mice. Tau hyperphosphorylation is restricted to axons but absent in cell bodies. (b) AT8-ir in the DG in a 6-month-old THY-Tau22 mice. Mossy fibers and molecular layer show tau hyperphosphorylation. (c) AT8-ir in the DG in a 15-month-old THY-Tau22 mice with massive degeneration of AT8-positive fibers and extensive AT8-ir of cell bodies fibers. Rare Gallyas-positive stained NFT-like inclusions were found in DG at this age (inset). (d) AD-specific AT100-ir indicative for abnormal tau phosphorylation in CA1 pyramidal neurons in THY-Tau22 at 12 months. (e) NFT-like inclusions (Gallyas positive) were found numerously in the CA1 and subiculum of THY-Tau22 at 12 months. (f) In 12-month-old THY-Tau22 mice, NT (Gallyas positive) occurred frequently in the subiculum (arrows). Representative photos are shown.

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