Chromosome gains and losses in normal and XP-V fibroblasts with or without p53 inhibition grown continuously for 20 passages. The genes are ordered by chromosome location from left to right and plotted against amplitude of copy number change. A, normal fibroblasts stably infected with the pRetro vector; B, vector- infected XP-V fibroblasts; C, normal fibroblasts stably infected with pRetro-p53; D, XP-V fibroblasts stably infected with pRetro-p53; E, SV40-transformed normal fibroblasts (GM637); F, SV40-transformed XP-V fibroblasts (XP30RO).