Table 1.
Phenotypes of human XP-V cells in which p53 is inactivated by different means and possible additional p53-dependent or independent mechanisms involved in viral transformed cells (see [23] and this study).
| Cell type |
P53 status | UV sensitivity |
Caffeine sensitization |
Apoptosis (A) or senescence (S) |
Additional possible mechanisms |
|---|---|---|---|---|---|
| Normal | Normal | Normal | Normal | S | --------------- |
| SV40 | Large T complex |
+ | +++ | A | Enhanced UV apoptosis by p53 |
| HPV16 (E6/E7) |
Degraded | +++ | No further increase in sensitivity |
S | ATR or HR targeted by E6 ubiquitination (?) |
| shRNA | Reduced expression |
+ | Same as in normal cells |
S | ------------------- |