Table 3.

Association of individual biomarkers with recurrent cardiovascular events among persons with coronary artery disease

	Linear Analysis (per SD)*		High Quartile vs. Lower Three Quartiles†
	HR (95% CI)	p-value	HR (95% CI)	p-value
Nt-proBNP
Unadjusted	2.13 (1.82 - 2.51)	<0.001	3.81 (2.73 - 5.30)	<0.001
Adjusted‡	1.67 (1.35 - 2.06)	<0.001	2.13 (1.43 - 3.18)	<0.001
Cystatin C
Unadjusted	1.59 (1.42 - 1.78)	<0.001	3.16 (2.27 - 4.39)	<0.001
Adjusted‡	1.54 (1.32 - 1.80)	<0.001	1.72 (1.10 - 2.70)	0.02
Albuminuria
Unadjusted	1.59 (1.39 - 1.81)	<0.001	2.87 (1.90 - 4.34)	<0.001
Adjusted‡	1.39 (1.18 - 1.63)	<0.001	1.71 (1.15 - 2.54)	0.008
C-Reactive Protein
Unadjusted	1.58 (1.33 - 1.87)	<0.001	2.58 (1.80 - 3.69)	<0.001
Adjusted‡	1.52 (1.26 - 1.82)	<0.001	2.00 (1.40 - 2.85)	<0.001
Interleukin – 6
Unadjusted	1.77 (1.50 - 2.10)	<0.001	2.39 (1.72 - 3.34)	<0.001
Adjusted‡	1.55 (1.28 - 1.87)	<0.001	1.76 (1.22 - 2.53)	0.003
Fibrinogen
Unadjusted	1.44 (1.21 - 1.71)	<0.001	1.50 (1.05 - 2.15)	0.03
Adjusted‡	1.26 (1.04 - 1.52)	0.02	1.15 (0.78 - 1.69)	0.48

Nt-proBNP: N-terminal prohormone brain natriuretic peptide

^*Linear analysis performed using log transformed concentrations of biomarkers

^†Cutpoints for high quartiles are as follows: Nt-proBNP >459pg/ml; cystatin C >1.3mg/L; albuminuria >19.5mg/g; CRP >4.93mg/L; IL-6 > 4.2mg/L; and fibrinogen >443mg/dL.

^‡Adjusted for age, sex, race, diabetes, BMI, current smoking, prior myocardial infarction, cerebrovascular accident, chronic heart failure, ejection fraction <50, hypertension, creatinine and acetylsalicylic acid use