Figure 2.

The in vivo apoptotic response after drug exposure. Cohorts of Msh2 +/+ or −/− animals were given i.p. injections of 50mg/kg MNNG (A); 100 mg/kg temozolomide (B); or 10mg/kg cisplatin (C) at time zero. The data show the means of the prevalence of apoptotic bodies per 50 half crypts. Each point represents data from a minimum of three mice. Closed circles, Msh2 +/+; open circles, Msh2 −/−. Error bars represent SEM. The difference between +/+ and −/− mice was significant for all three drugs at 6 and 12 hours (P < 0.05, Mann–Whitney U test). Significant differences also were seen for temozolomide-treated animals at 24 and 48 hours and for Cisplatin treated mice at 24, 48, and 72 hours.