Table 2.
FEZ1 aberrant transcripts observed in cancers
| Tumor | Deletion | Results | Affected exons | Putative protein coded in-frame |
|---|---|---|---|---|
| E16 | 156-1542 | FS | Ex1,2,3 | Zip(−) |
| E26 | 558-1715 | IF | Ex2,3 | Zip(−) |
| E41 | 558-1715 | IF | Ex2,3 | Zip(−) |
| E62 | 558-1715 | IF | Ex2,3 | Zip(−) |
| TE8 | 156-1542 | FS | Ex1,2,3 | Zip(−) |
| 1402-1578 | IF | Ex3 | Zip(+) | |
| DU145 | 1366-1641 | IF | Ex3 | Zip(+) |
| 1402-1578 | IF | Ex3 | Zip(+) | |
| MOLT4 | 1402-1578 | IF | Ex3 | Zip(+) |
| G361 | 1417-1515 | IF | Ex3 | Zip(+) |
| 1516-1584 | IF | Ex3 | Zip(+) |
The positions of the first and last nucleotides of deletions are shown according to the nucleotide number counted from the first coding codon. IF, in-frame; FS, frameshift; Zip(+), putative Fez1 protein coded in-frame with leucine zipper: Zip(−), protein without leucine zipper.