Figure 4.

In vivo effects of βARKct expression on balloon-injured rat carotid arteries. (A) Histologic staining of a normal, untreated rat carotid artery. (B– D) Sections of representative rat carotid segments 28 days after balloon injury. Restenosis and intimal hyperplasia are evident in injured arteries not treated (B) or treated with the empty adenovirus (C). This proliferative response was attenuated significantly and not as prominent in injured arteries treated with the βARKct adenovirus (D).