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The in vivo effect of RFB4-RTA peptides. (A) SCID mice with human xenografts were injected with 200 μg of RFB4-dgRTA (□), RFB4-LDV+ (⊠), RFB4-GQT (▨), or saline (■), and the wet/dry weight ratios of the human skin were determined. (B) SCID mice were injected as described in A and the wet/dry weight ratios of lungs were determined. Values represent the mean of three experiments ± SD. Asterisks indicate a significant difference from saline-treated mice (∗, P < 0.02; ∗∗, P < 0.01).
