Figure 1. RGS9 KO Mice Exhibit Deficits in Motor Coordination but Normal Locomotor Activity.
(A) RGS9 KO mice have deficits in motor coordination as measured on the accelerating rotarod. ANOVA revealed a main effect of genotype [F1,20 = 5.64, p = 0.028], a main effect of trial, [F26,520 = 4.82, p < 0.000001 ] but no interaction between genotype and trial, [F26,520 = 1.26, p=0.18]. (B) Mean time to fall off rotarod over trails 8-27 in RGS9 KO and WT (p=5.05×10-12). (C)RGS9 KO mice show similar locomotor activity as WT in a 10 min open field test (p = 0.76).
